EPRS/GluRS promotes gastric cancer development via WNT/GSK-3β/β-catenin signaling pathway.

Hui LiuMangaladoss FredimosesPeijia NiuTingting LiuYan QiaoXueli TianXiaobing ChenDong Joon KimXiang LiKangdong LiuZhenxiang Zhang

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)

These findings unveil a promising strategy for GC prevention and therapy by targeting EPRS-mediated WNT/GSK-3β/β-catenin cascades. Moreover, XA and 4-HD may be effective reagents used for GC prevention and therapy.

Keyphrases

cell proliferation
stem cells
signaling pathway
pi k akt
epithelial mesenchymal transition
gas chromatography
smoking cessation