Establishment of a Rat Model of Liver Venous Deprivation: Simultaneous Portal and Hepatic Vein Ligation.
Yuefeng ZhangXiaoqin HePeng MaLiangkun XiongWenhui BaiGaoshuo ZhangYangtao XuWei SongKai-Huan YuPublished in: Journal of clinical and translational hepatology (2022)
We describe the first rat model of LVD and e-LVD with simultaneously associated HVL and PVL. Compared with the ALPPS technique, the LVD or e-LVD procedure had a comparable overall effect on the hypertrophy response and a stronger effect on liver function. The SPHK1/S1P/S1PR1 pathway was involved in the LVD- or ALPPS-induced liver remodeling.