Association of cytokine profile with prior treatment failure and revision surgery in chronic rhinosinusitis.
Elizabeth S LonginoAlex B LabbyJeffanie WuNikita ChapurinPing LiRakesh K ChandraJustin H TurnerNaweed I ChowdhuryPublished in: International forum of allergy & rhinology (2022)
In CRSwNP, elevated IL-5 and IL-13 levels were higher at time of surgery in patients with more prior surgeries. Type 2 cytokines in CRSsNP demonstrated mixed associations with revision surgery. For both phenotypes, IL-10, IL-12, and IL-21 were consistently lower as number of prior surgeries increased, suggesting that treatment-resistant disease may be modulated by impairment in these signaling pathways.