Personalizing non-small cell lung cancer treatment through patient-derived xenograft models: preclinical and clinical factors for consideration.
Vered FuchsAriel SobarzoMaha MsamraYarden KezerleLiat LindeGur SevillyaAlaa AnozeYael RefaelyAhron Yehonatan CohenIsrael MelamedAmit AzrielRami ShoukrunYael RavivAngel PorgadorNir PeledLaila Catalina RoismanPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
Our study highlights the impact of multiple clinical and preclinical factors on the engraftment success, growth kinetics, and tumor stability of patient-specific NSCLC PDXs, and underscores the importance of considering these factors when guiding and evaluating prolonged personalized treatment studies for NSCLC patients in these models, as well as signaling the imperative for additional investigations to determine the full clinical potential of this technique.