Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.

Nao KomatsuMikihito KajiyaSouta MotoikeManabu TakewakiSusumu HorikoshiTomoyuki IwataKazuhisa OuharaKatsuhiro TakedaShinji MatsudaTsuyoshi FujitaHidemi Kurihara

Published in: Stem cell research & therapy (2018)

These findings suggest that OIM-C-MSCs, which form a unique microenvironment that maintains high YAP/TAZ activity, can serve as better candidates for bone regenerative cell therapy than C-MSCs.

Keyphrases

cell therapy
mesenchymal stem cells
extracellular matrix
umbilical cord
stem cells
bone marrow
bone mineral density
mouse model
bone regeneration