A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.

Haiping Duan Wanxue Song Weijing Wang Hainan Cao Bingling Wang Yan Liu Chunsheng Xu Yili Wu Zengchang Pang Dongfeng Zhang

Published in: BioMed research international (2021)

The genetic variations reported herein are significantly involved in functional genes and regulatory domains that mediate ARHI pathogenesis. These findings provide clues for the further unraveling of the molecular physiology of hearing functions and identifying novel diagnostic biomarkers and therapeutic targets of ARHI.

Keyphrases

genome wide association study
genome wide
hearing loss
transcription factor
dna methylation
copy number
genome wide identification
gestational age
bioinformatics analysis
gene expression