Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer.
Jill C RubinsteinAli Foroughi PourJie ZhouTodd B SheridanBrian S WhiteJeffrey H ChuangPublished in: Journal of surgical oncology (2022)
Deep learning provides spatially resolved visualization of imaging-derived biomarkers and automated quantification of tumor heterogeneity. Our novel THS correlates with MSI-status, indicating that with expanded training sets, translational tools could be developed that predict MSI-status using H&E-stained images alone.