Liquid Biopsy by ctDNA in Liver Transplantation for Colorectal Cancer Liver Metastasis.

Chase J WehrleRoma RajNihal AykunDanny OrabiBassam EstfanSuneel KamathSmitha KrishnamurthiMasato FujikiKoji HashimotoCristiano QuintiniDavid Choon Hyuck KwonTeresa Diago-UsoKazunari SasakiFederico N Aucejo

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2023)

Liver transplantation for liver-confined unresectable CRLM is emerging as a valid surgical option in selected patients. The significance of liquid biopsy in this population remains elusive due to lack of data. The clearance of ctDNA after transplant in these patients with metastatic disease and despite their immunosuppression is notable. The significance and usefulness of liquid biopsy in patient selection, surveillance, and as an indication for treatment warrant further investigation.

Keyphrases

ultrasound guided
end stage renal disease
fine needle aspiration
ionic liquid
ejection fraction
newly diagnosed
chronic kidney disease
public health
prognostic factors
peritoneal dialysis
circulating tumor
big data
patient reported outcomes
locally advanced
machine learning
patient reported
smoking cessation