Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
Rajarshi MukherjeeOlga A MareninovaIrina V OdinokovaWei HuangJohn MurphyMichael ChvanovMuhammad A JavedLi WenDavid M BoothMatthew C CaneMuhammad AwaisBruno GavilletRebecca M PrussSophie SchallerJeffery D MolkentinAlexei V TepikinOle H PetersenStephen J PandolIlya GukovskyDavid N CriddleAnna S GukovskayaRobert Suttonnull nullPublished in: Gut (2015)
This work demonstrates the mechanism and consequences of MPTP opening to be fundamental to multiple forms of acute pancreatitis and validates the MPTP as a drug target for this disease.