High-grade serous carcinoma with discordant p53 signature: report of a case with new insight regarding high-grade serous carcinogenesis.

Yuichiro HatanoShinya FukudaHiroshi MakinoHiroyuki TomitaKen-Ichirou MorishigeAkira Hara

Published in: Diagnostic pathology (2018)

Recent evidence suggests that p53 signature is the putative precursor of p53 overexpression-type HGSC. Because the putative precursors of the other p53 immunophenotypical HGSC are not proposed, we presume γ-H2AX-expressing cells without p53 overexpression may be a potent candidate of null-type TP53-mutated tubal cells, which are named "γ-H2AX responsive foci."

Keyphrases

high grade
low grade
induced apoptosis
cell cycle arrest
cell proliferation
transcription factor
endoplasmic reticulum stress
cell death
signaling pathway
drug delivery
pi k akt
anti inflammatory