Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage.

Hodaka OgawaShunichi YokotaYumeka HosoiAyano ShindoNaho OgawaRyodai YamamuraTomohiro ShimizuIssei NakadeSuishin AraiMai TaniguchiYuka NishibataSakiko MasudaDaigo NakazawaUtano TomaruNorimasa IwasakiAkihiro Ishizu

Published in: Lupus science & medicine (2023)

PCYOX1 and related factors are worthy of attention to understand the underlying mechanisms and create novel therapeutic strategies for mPSL-mediated microcirculation disorders, including ONFH.

Keyphrases

systemic lupus erythematosus
high glucose
diabetic rats
working memory
blood pressure
high dose
high fat diet induced
disease activity
drug induced
oxidative stress
extracellular matrix
endothelial cells
metabolic syndrome
adipose tissue