Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.
Paramita ChakrabortyRasesh Y ParikhSeungho ChoiDanh TranMonika GoozZachariah T HedleyDo-Sung KimDariusz PytelInhong KangSatish N NadigGyda C BeesonLauren E BallMeenal MehrotraHongjun WangStefano BertoViswanathan PalanisamyHong LiShilpak ChatterjeePaulo C RodriguezEduardo N MaldonadoJ Alan DiehlVamsi K GangarajuShikhar MehrotraPublished in: Cancer research (2022)
Transient activation of ER stress with carbon monoxide drives mitochondrial biogenesis and protective autophagy that elicits superior antitumor T-cell function, revealing an approach to improving adoptive cell efficacy therapy.