Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging.
Xinfeng YuXinzhen YinHui HongShuyue WangYeerfan JiaerkenFan ZhangOfer PasternakRuiting ZhangLinglin YangMin LouMinming ZhangPeiyu HuangPublished in: Fluids and barriers of the CNS (2021)
Our study demonstrated that increased ECF was associated with WM degeneration and the occurrence of lacunes and microbleeds, providing important new insights into the role of ECF in CADASIL pathology. Improving ECF drainage might become a therapeutic strategy in future.