Differential impact of tumor suppressor gene (TP53, PTEN, RB1) alterations and treatment outcomes in metastatic, hormone-sensitive prostate cancer.

Miguel Gonzalez VelezHeidi E KosiorekJan B EganAndrea L McNattyIrbaz B RiazSteven R HwangGlenn A StewartThai H HoCassandra N MooreParminder SinghRenee K SharpstenBrian A CostelloAlan H Bryce

Published in: Prostate cancer and prostatic diseases (2021)

The presence of TSG-alt outperforms clinical criteria for predicting early progression during first-line treatment of M1-HSPC. ADT + A was less effective in patients with than without TSG-alt. Confirmation of these findings may establish the need for inclusion of molecular stratification in treatment algorithms.

Keyphrases

prostate cancer
machine learning
small cell lung cancer
squamous cell carcinoma
radical prostatectomy
cell proliferation
copy number
genome wide
pi k akt
genome wide identification
replacement therapy
genome wide analysis