A Natural Chalcone Cardamonin Inhibited Transformation of Aryl Hydrocarbon Receptor Through Binding to the Receptor Competitively.

Tianshun ZhangChao HeShieru OtaTomoya KitakazeRyoichi YamajiSayuri ShimazuYoko YamashitaHitoshi Ashida

Published in: Molecular nutrition & food research (2024)

Among used chalcones, a natural chalcone cardamonin competitively binds to AhR and suppresses its transformation. Thus, cardamonin is an effective food factor for suppression of the dioxin-caused biochemical alterations and toxicities.

Keyphrases

signaling pathway
risk assessment
human health
climate change