A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits.
Basten L SnoekRita J M VolkersHarm NijveenCarola PetersenPhilipp DirksenMark G SterkenRania NakadJoost A G RiksenPhilip RosenstielJana J StastnaBart P BraeckmanSimon C HarveyHinrich SchulenburgJan E KammengaPublished in: BMC biology (2019)
Taken together, we show that using more parents than the classical two parental genotypes to construct a RIL population facilitates the detection of QTLs and that the use of wild isolates facilitates the detection of QTLs. The use of multi-parent RIL populations can further enhance our understanding of local adaptation and life history trade-offs.