Naphthalimide-based Functional Glycopolymeric Nanoparticles as Fluorescent Probes for Selective Imaging of Tumor Cells.
Yi LiZhi CaiJieyu GuJinghua ChenYan ZhangPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
A series of functional glycopolymer nanoparticles with 1,8-naphthalimide motif was designed, synthesized and applied for tumor cell imaging. With the pH-sensitive and aggregation-induced emission (AIE) effect of the 1,8-naphthalimide fluorescent probe, the presence of glucose-based glycopolymers enhanced its water-solubility and biocompatibility. Owing to the dual tumor-targeting effects of the dense glucose part and the boronic ester modification, the obtained glycopolymers showed high affinity to tumor cells, with a much faster staining rate than normal cells, indicating a great potential for diagnosis and treatments of cancers.
Keyphrases
- fluorescent probe
- living cells
- high resolution
- induced apoptosis
- blood glucose
- single cell
- fluorescence imaging
- cell therapy
- cancer therapy
- stem cells
- cell cycle arrest
- type diabetes
- bone marrow
- metabolic syndrome
- adipose tissue
- drug delivery
- small molecule
- photodynamic therapy
- flow cytometry
- cell proliferation
- weight loss
- endoplasmic reticulum stress
- pi k akt
- skeletal muscle
- tissue engineering