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Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations.

William BoisseauPhilipp EuskirchenKarima MokhtariCaroline DehaisMehdi TouatKhê Hoang-XuanMarc SansonLaurent CapelleAurélien NouetCarine KarachiFranck BielleJustine GuéganYannick MarieNadine Martin-DuverneuilLuc TaillandierAudrey RousseauJean-Yves DelattreAhmed Idbaih
Published in: The oncologist (2019)
Astroblastoma (ABM) remains a poorly defined and controversial entity. Although meningioma 1 alterations seem to define a large subset of pediatric cases, adult cases remain molecularly poorly defined. This comprehensive molecular characterization of 1 adolescent and 14 adult ABM revealed that adult ABM histology comprises several molecularly defined entities, which explains clinical diversity and identifies actionable targets. Namely, pleomorphic xanthoastrocytoma-like ABM cases show a favorable prognosis whereas high-grade glioma (glioblastoma and diffuse midline gliome)-like ABM show significantly worse clinical courses. These results call for in-depth molecular analysis of adult gliomas with astroblastic features for diagnostic and therapeutic purposes.
Keyphrases
  • high grade
  • childhood cancer
  • low grade
  • young adults
  • mental health
  • genome wide
  • optical coherence tomography
  • tyrosine kinase