LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.

Fangyuan LiuWeimin XuYaosheng WangZhenyu HuangZhehui ZhuWeijun OuWenbo TangJihong FuChenying LiuYubei GuYun LiuPeng Du

Published in: Inflammatory bowel diseases (2023)

We propose that LAMB3 could serve as a potential therapeutic target of IBD and a predictor of intestinal stenosis of Crohn's disease. Our findings demonstrate the important role of ECM in the progression of IBD and offer an experimental basis for the treatment and prognosis of IBD.

Keyphrases

ulcerative colitis
oxidative stress
extracellular matrix
combination therapy
risk assessment
human health
climate change