Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.

Mengyan XieTao YuXinming JingLing MaYu FanFengming YangPei MaHuning JiangXi WuYongqian ShuTongpeng Xu

Published in: Molecular cancer (2020)

Our findings demonstrate that exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. circSHKBP1 is a promising circulating biomarker for GC diagnosis and prognosis and an exceptional candidate for further therapeutic exploration.

Keyphrases

heat shock protein
vascular endothelial growth factor
endothelial cells
heat shock
heat stress
signaling pathway
binding protein
gas chromatography
mass spectrometry
solid phase extraction