A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors.

Emiri Omori Takaki Kunihiko Kiyono Yutaka Obuchi Takeshi Yamauchi Takashi Watanabe Hideki Matsumoto Miho Karimine Yuki Kuniyoshi Shingo Nishikori Fumiharu Yokoyama Hikaru Nishimori Hiroshi Nabeshima Kazuhide Nakamura

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These findings suggest that OPB-171775, with its significant efficacy, could potentially serve as a novel and effective treatment option for advanced GISTs, particularly those resistant to TKIs.

Keyphrases

tyrosine kinase
combination therapy
single molecule
chronic myeloid leukemia