Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality.
Aurélien PhilippeRichard ChocronNicolas GendronOlivier BoryAgathe BeauvaisNicolas PeronLina KhiderCoralie L GuerinGuillaume GoudotFrançoise LevasseurChristophe PeroninoJerome DucheminJulie BrichetElise SourdeauFlorence DesvardSébastien BertilFrédéric PeneCherifa CheurfaTali-Anne SzwebelBenjamin PlanquetteNadia RivetGeorges JourdiCaroline Hauw-BerlemontBertrand HermannPascale GaussemTristan MiraultBenjamin TerrierOlivier SanchezJean-Luc DiehlMichaela FontenayDavid M SmadjaPublished in: Angiogenesis (2021)
VWF:Ag is a relevant predictive factor for in-hospital mortality in COVID-19 patients. More than a biomarker, we hypothesize that VWF, including excess of HMWM forms, drives microthrombosis in COVID-19.