Salvindolin elicits opioid system-mediated antinociceptive and antidepressant-like activities.

Adam W KeaslingPankaj PandeyRobert J DoerksenGustavo R PedrinoElson A CostaLuiz C da CunhaJames Oluwagbamigbe FajemiroyeJames O Fajemiroye

Published in: Journal of psychopharmacology (Oxford, England) (2019)

By simple chemical modification, we were able to modulate the pharmacological profile of salvinorin A, a highly selective kappa opioid receptor agonist, to salvindolin, a ligand with preferential mu opioid receptor affinity and activity on the serotonin 1A receptor. With its significant antinociceptive and antidepressive-like activities, salvindolin has the potential to be an analgesic and/or antidepressant drug candidate.

Keyphrases

chronic pain
pain management
major depressive disorder
anti inflammatory
nuclear factor
risk assessment
toll like receptor
spinal cord injury
adverse drug