miR-378a regulates keratinocyte responsiveness to interleukin-17A in psoriasis.

Ping XiaLorenzo PasqualiChenying GaoAnkit SrivastavaNupur KheraJan Cedric FreisenhausenLonglong LuoEinar RosénAnke van LieropBernhard HomeyAndor Pivarcsi Enikö Sonkoly

Published in: The British journal of dermatology (2022)

Collectively, our findings identify miR-378a as an amplifier of IL-17A-induced NF-κB signalling in keratinocytes and suggest that increased miR-378a levels contribute to the amplification of IL-17A-driven skin inflammation in psoriasis.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
oxidative stress
signaling pathway
pi k akt
high glucose
endothelial cells
nuclear factor
nucleic acid
toll like receptor
hidradenitis suppurativa