Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma.

Jasmin LauziFabian AndersHanhan LiuNorbert PfeifferFranz GrusSolon ThanosStefan ArnholdVerena Prokosch

Published in: PloS one (2019)

CRMP-5 seems to play an important role in an animal model of glaucoma. Addition of CRMP-5 exerts neuro-protective and neuro-regenerative effects in vitro. This effect could be mediated via activation of PKB affecting intra-cellular apoptosis pathways.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
stem cells
pi k akt
optic nerve
oxidative stress
cataract surgery
signaling pathway
tissue engineering
cell proliferation
brain injury