A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing.

Miguel Gonzalez-MuñozJaime Monserrat VillatoroEva Marín-SerranoStefan StewartBelén Bardón RiveraJesús MarínLucía Martínez de SotoEnrique Seco MeseguerElena Ramírez García

Published in: Clinical case reports (2020)

A 56-year-old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.

Keyphrases

drug induced
adverse drug
case report
major depressive disorder
healthcare
emergency department
clinical evaluation