Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19.
Mukundan AtturChristopher PetrilliSamrachana AdhikariEduardo IturrateXiyue LiStephanie TuminelloNan HuAravinda ChakravartiDavid BeckSteven B AbramsonPublished in: The Journal of infectious diseases (2024)
The IL1RN haplotype CTA and C/C variant of rs419598 are associated with attenuation of the CRS and decreased mortality in men with acute SARS-CoV-2 infection. The data suggest that the IL1RN pathway modulates the severity of coronavirus disease 2019 (COVID-19) via endogenous anti-inflammatory mechanisms.
Keyphrases
- coronavirus disease
- respiratory syndrome coronavirus
- sars cov
- cardiovascular events
- anti inflammatory
- copy number
- liver failure
- genome wide
- electronic health record
- coronary artery disease
- big data
- respiratory failure
- case report
- gene expression
- cardiovascular disease
- machine learning
- middle aged
- intensive care unit
- transcription factor
- extracorporeal membrane oxygenation