What is the role of the thioredoxin antioxidant complex in relation to HAM/TSP?
Masoud YoussefiKiarash GhazviniJorge CassebMasoud KeikhaPublished in: Access microbiology (2020)
We have little information about the definite role of the thioredoxin antioxidant complex system during viral infection, particularly during human T-cell lymphotropic virus type 1 (HTLV-1) infection and the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) state. Therefore, we conducted comprehensive next-generation sequencing (NGS) analysis to determine Trx system expression changes in three categories of subjects: sero-negative HTLV-1 individuals, asymptomatic HTLV-1 people and HAM/TSP patients. We found that Trx capacity is reduced in the HAM/TSP state compared to healthy individuals, which indicates increasing inflammation and reduction of apoptosis, which might contribute to the progression of inflammation in the spinal cord, which in turn may develop into the HAM/TSP state.
Keyphrases
- oxidative stress
- spinal cord
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- anti inflammatory
- prognostic factors
- neuropathic pain
- cell death
- endoplasmic reticulum stress
- gene expression
- healthcare
- signaling pathway
- cell cycle arrest
- induced pluripotent stem cells
- fluorescent probe
- health information
- genome wide