The safety of cardioselective β1-blockers in asthma: literature review and search of global pharmacovigilance safety reports.

Miriam R BennettCatherina L ChangMichael TatleyRuth SavageRobert J Hancox

Published in: ERJ open research (2021)

There were no published reports of cardioselective β1-blockers causing asthma death. Observational data suggest that cardioselective β1-blocker use is not associated with increased asthma exacerbations. We found only one report of an asthma death potentially caused by cardioselective β1-blockers in a patient with asthma in a search of VigiBase. The reluctance to use cardioselective β1-blockers in people with asthma is not supported by this evidence.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
angiotensin converting enzyme
cystic fibrosis
case report
emergency department
systematic review
angiotensin ii
drug induced