Proteomics analysis of prefrontal cortex of Alzheimer's disease patients revealed dysregulated proteins in the disease and novel proteins associated with amyloid-β pathology.

Ana Montero-CalleRaquel CoronelMaría Garranzo-AsensioGuillermo Solís-FernándezAlberto RábanoVivian de Los RíosMaría Jesús Fernández-AceñeroMarta L MendesJavier Martínez-UserosDiego MegíasMaría-Teresa Moreno-CasbasAlberto Peláez-GarcíaIsabel ListeRodrigo Barderas

Published in: Cellular and molecular life sciences : CMLS (2023)

We identified and validated novel AD-associated proteins in brain tissue that should be of further interest for the study of the disease. Remarkably, PMP2 and SCRN3 were found to bind to amyloid-β (Aβ) fibers in vitro, and PMP2 to associate with Aβ plaques by IF, whereas HECTD1 and SLC12A5 were identified as new potential blood-based biomarkers of the disease.

Keyphrases

prefrontal cortex
mass spectrometry
end stage renal disease
brain injury
resting state
peritoneal dialysis
white matter