Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences.

Shuling ChenCheng HuangGuanrui LiaoHuichuan SunYubin XieChangyi LiaoJianping WangMinghui HeHuanjing HuZihao DaiXiaoxue RenXuezhen ZengZhilong LinGuo-Pei ZhangWenxuan XieShunli ShenShaoqiang LiSui PengDong-Ming KuangQiang ZhaoDan G Duda Ming Kuang

Published in: Gut (2023)

True and de novo HCC recurrences occur early, have distinct TIME and may require different immunotherapy strategies. Our study provides a source for genomic diagnosis and immune profiling for guiding immunotherapy based on the type of HCC recurrence and the specific TIME.

Keyphrases

single cell
rna seq
hepatitis b virus
climate change
copy number
liver failure
gene expression
dna methylation
free survival