Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.

Vincent PlancheIsmail KoubiyrJosé E RomeroJosé V ManjonPierrick CoupéMathilde DeloireVincent DoussetBruno BrochetAurélie RuetThomas Tourdias

Published in: Human brain mapping (2018)

The hippocampal degenerative process spread from dentate gyrus to CA1 at the earliest stage of MS. This dynamic vulnerability is associated with MS diagnosis after CIS and will ultimately impact hippocampal-dependent memory performance.

Keyphrases

multiple sclerosis
climate change
mass spectrometry
cerebral ischemia
ms ms
temporal lobe epilepsy
white matter
working memory
blood brain barrier