Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction.

Sibel Köktürk Erdal Benli Ali Ayyıldız Selma Cırrık Yeliz Cetinkol Sema Nur Ayyıldız Tevfik Noyan

Published in: Revista da Associacao Medica Brasileira (1992) (2019)

The phosphodiesterase type 5 inhibitor's tadalafil reduced expressions of α-SMA and TGF-β in the obstructed ureters, measured by biochemical examinations. In addition, tadalafil decreased urothelium degeneration due to the decreased epithelial cell loss and inflammatory cell infiltration. Our results show that tadalafil prevents or slows down the onset of ureter inflammation and urothelial degeneration in rats with UUO.

Keyphrases

lower urinary tract symptoms
benign prostatic hyperplasia
oxidative stress
urinary tract
single cell
transforming growth factor
stem cells
mouse model
signaling pathway
metabolic syndrome
skeletal muscle
weight loss