Evolution of white matter damage in amyotrophic lateral sclerosis.
Matt C GabelRebecca J BroadAlexandra L YoungSharon AbrahamsMark E BastinRicarda A L MenkeAmmar Al-ChalabiLaura H GoldsteinStella TsermentseliDaniel C AlexanderMatthew C KiernanP Nigel LeighMara CercignaniPublished in: Annals of clinical and translational neurology (2020)
These findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.