Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping.

Karl PayneJill BrooksNikolaos BatisNaeem KhanMohammed El-AsragPaul NankivellHisham MehannaGraham S Taylor

Published in: British journal of cancer (2023)

We demonstrate mass cytometry allows high-plex proteomic characterisation of CTCs at single-cell resolution and identify common CTC sub-groups with potential for novel biomarker development and immune checkpoint inhibitor treatment stratification.

Keyphrases

single cell
rna seq
high throughput
circulating tumor cells
induced apoptosis
cell cycle arrest
label free
signaling pathway
risk assessment
human health
cell free