Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model.

Ayumu KawakuboMasayuki MiyagiYuji YokozekiMitsufumi NakawakiShotaro TakanoMasashi SatohMakoto ItakuraGen InoueMasashi TakasoKentaro Uchida

Published in: International journal of immunopathology and pharmacology (2022)

Our findings suggest that M2 Mϕ following IVD injury may originate from resident Mϕ. TGF-β is a key factor for M2 polarization of macrophages following IVD injury.

Keyphrases

transforming growth factor
patient safety
type diabetes
metabolic syndrome
quality improvement
high fat diet induced
skeletal muscle
signaling pathway
epithelial mesenchymal transition
insulin resistance