Local and systemic diffusion of antineoplastic drugs following vertebroplasty using acrylic cement mixed with cisplatin or methotrexate: experimental study in pigs.

Rafael Llombart-BlancoCarlos VillasÁlvaro SilvaAzucena AldazIñigo NavarroJeronimo FortezaSalvador Martin AlgarraMatías Alfonso

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2017)

There is local diffusion of antineoplastic agents from the cement to bone and plasma. We found methotrexate and cisplatin levels in bone at up to 5 weeks, comparable to previous in vitro reports. At the doses administered, there were no cases of myelosuppression, hepatotoxicity, or nephrotoxicity.

Keyphrases

drug induced
bone mineral density
high dose
soft tissue
bone loss
bone regeneration
adverse drug
emergency department
low dose
body composition
preterm birth