Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway.
Bin ZhengYakun YangJinghan LiJing LiSaijie ZuoXi ChuShan XuDonglai MaLi ChuPublished in: Drug design, development and therapy (2021)
Our data showed that MgIG alleviates ATO-induced cardiotoxicity, which is associated to the anti-inflammation, anti-oxidation, and anti-apoptosis action, potentially through activation of the Nrf2 pathway and suppression of the TLR4/NF-κB pathway.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- pi k akt
- high glucose
- nuclear factor
- toll like receptor
- inflammatory response
- lps induced
- induced apoptosis
- drug induced
- cell cycle arrest
- electronic health record
- cell death
- drinking water
- epithelial mesenchymal transition
- big data
- heavy metals
- endothelial cells
- cell proliferation
- artificial intelligence
- machine learning
- deep learning