Systemic Treatments and Molecular Biomarkers for Perivascular Epithelioid Cell Tumors: A Single-institution Retrospective Analysis.

Stefano Testa Nam Q Bui Kristen N Ganjoo

Published in: Cancer research communications (2023)

This study examines systemic treatments for advanced PEComas, a rare group of sarcomas, and identifies molecular biomarkers of prognosis. Our results show that mTOR inhibitors have similar efficacy as chemotherapy, and that TFE3 overexpression, on IHC or FISH, correlates with a more aggressive disease course.

Keyphrases

cell proliferation
single cell
cell therapy
transcription factor
high grade
stem cells
locally advanced
gene expression
radiation therapy
bone marrow
chemotherapy induced