Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy.

Ke MaBo ZhuZetao WangPeian CaiMingwei HeDanyan YeGuohua YanLi ZhengLujun YangJinmin Zhao

Published in: Journal of nanobiotechnology (2020)

C-EVs play an essential role in fostering chondrogenic differentiation and proliferation of HUCMSCs, which may be beneficial for articular cartilage repair.

Keyphrases

mesenchymal stem cells
umbilical cord
signaling pathway
endothelial cells
bone marrow
cell death
cell therapy
oxidative stress
induced pluripotent stem cells
endoplasmic reticulum stress
stem cells