Peripheral Immune Profiles Predict ALS Progression in an Age- and Sex-Dependent Manner.
Benjamin J MurdockBangyao ZhaoKristen D PawlowskiJoshua P FamieCaroline E PiecuchIan F Webber-DavisSamuel J TeenerEva L FeldmanLili ZhaoStephen A GoutmanPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Specific immune profiles likely contribute to ALS progression in an age and sex-dependent manner, and peripheral immune markers enhance the prediction of short-term clinical outcomes. These findings suggest a complex milieu of immune profiles associated with ALS progression, and more detailed immunophenotyping in ALS will facilitate personalized immunotherapeutics in ALS.