Definition of early age at onset in bipolar disorder according to distinctive neurodevelopmental pathways: insights from the FACE-BD study.

Filippo CorponiAntoine LefrereMarion LeboyerFrank BellivierOphelia GodinJosephine LoftusPhilippe CourtetCaroline DubertretEmmanuel HaffenPierre Michel LlorcaPaul RouxMircea PolosanRaymund SchwanLudovic SamalinEmilie OliéBruno Etainnull nullPeggy SerièsRaoul Belzeaux

Published in: Psychological medicine (2023)

Early AAO best captures distinctive neurodevelopmental patterns when defined as ⩽17 years. GMM-based definition of early AAO falls short of mapping to highly distinguishable neurodevelopmental pathways. These results should be used to improve patients' stratification in future studies of BD pathophysiology and biomarkers.

Keyphrases

bipolar disorder
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
major depressive disorder
congenital heart disease