Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation.
Siqin ZhangShaoyong ChenPian AoRong CaiWenqi LiuLi WeiPublished in: International journal of radiation biology (2022)
These findings suggest that LJP early treatment may mitigate radiation-induced cognitive impairments and that its mechanism may relate to its protection of neurogenesis by alleviating neuroinflammation and collagen IV degradation within the neurogenic microenvironment.
Keyphrases
- radiation induced
- cerebral ischemia
- radiation therapy
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- subarachnoid hemorrhage
- cognitive impairment
- stem cells
- neural stem cells
- wound healing
- blood brain barrier
- working memory
- tissue engineering
- inflammatory response
- skeletal muscle
- insulin resistance
- water soluble