Migraine-provoking substances evoke periorbital allodynia in mice.

Francesco De LoguLorenzo LandiniMalvin N JanalSimone Li PumaFrancesco De CesarisPierangelo GeppettiRomina Nassini

Published in: The journal of headache and pain (2019)

The correspondence between substances that provoke (CGRP; PACAP, histamine, PGE2, PGI2), or do not provoke (VIP and PGF2α), migraine-like attacks in patients and periorbital allodynia in mice suggests that the study of allodynia in mice may provide information on the proalgesic mechanisms of migraine-provoking agents in humans. Results underline the ability of migraine-provoking substances to initiate mechanical allodynia by acting on peripheral terminals of trigeminal afferents.

Keyphrases

neuropathic pain
high fat diet induced
end stage renal disease
drinking water
spinal cord
spinal cord injury
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
healthcare
wild type
insulin resistance
patient reported outcomes
social media