Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity.
Chun-Lan XieTai-Zong WuYuan WangRobert J CaponRen XuXian-Wen YangPublished in: Organic letters (2024)
Two novel meroterpenoids, alliisativins A and B ( 1 , 2 ) were discovered through a genome-based exploration of the biosynthetic gene clusters of the deep-sea-derived fungus Penicillium allii-sativi MCCC entry 3A00580. Extensive spectroscopic analysis, quantum calculations, chemical derivatization, and biogenetic considerations were utilized to establish their structures. Alliisativins A and B ( 1 , 2 ) possess a unique carbon skeleton featuring a drimane sesquiterpene with a highly oxidized polyketide. Noteworthily, alliisativin A ( 1 ) showed dual activity in promoting osteogenesis and inhibiting osteoclast, indicating an antiosteoporosis potential.
Keyphrases
- genome wide
- molecular dynamics
- ms ms
- signaling pathway
- copy number
- liquid chromatography tandem mass spectrometry
- density functional theory
- molecular dynamics simulations
- high resolution
- dna methylation
- gas chromatography mass spectrometry
- monte carlo
- transcription factor
- human health
- bone loss
- climate change
- solid phase extraction