Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans.

Wen-Jou ChangMaria S BakerEleonora LaritskyChathura J GunasekaraUditha MadurangaJustine C GalliouJoseph W McFaddenJessica R WaltemyerBruce Berggren-ThomasBrianna N TateHanxue ZhangBenjamin D RosenCurtis P Van TassellGeorge E LiuCristian CoarfaYi Athena RenRobert A Waterland

Published in: Genome biology (2024)

Our data indicate that CoRSIVs exist in cattle, as in humans, suggesting these systemic epigenetic variants may be common to mammals in general. To the extent that individual epigenetic variation at cattle CoRSIVs affects phenotypic outcomes, assessment of CoRSIV methylation at birth may become an important tool for optimizing agriculturally important traits. Moreover, adjusting embryo culture conditions during assisted reproduction may provide opportunities to tailor agricultural outcomes by engineering CoRSIV methylation profiles.

Keyphrases

dna methylation
genome wide
copy number
gene expression
electronic health record
heavy metals
climate change
pregnant women
type diabetes
pregnancy outcomes
machine learning
skeletal muscle
weight loss