Prostaglandin E2 decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin.
Lucyna MastalerzKatarzyna E TyrakMaria IgnacakEwa KondurackaFilip MejzaAdam ĆmielMichał BuczekAdrianna KotKrzysztof OleśMarek SanakPublished in: Allergy (2018)
Aspirin-precipitated bronchoconstriction is associated with a decrease in airway PGE2 biosynthesis. These results support the mechanism of PGE2 biosynthesis inhibition as a trigger for bronchoconstriction in NERD.