Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities.
Jianxin HanWei LiuMiaomiao LiYanpei GuYing ZhangTao YuanPublished in: Molecules (Basel, Switzerland) (2020)
In the current study, further chemical investigation of the fruiting bodies of Fomes officinalis led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I-O (1-7). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds 1-3 possessed an unusual C-23 spirostructure moiety, while compounds 4-7 had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds 3 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).
Keyphrases
- anti inflammatory
- lps induced
- inflammatory response
- induced apoptosis
- high resolution
- mass spectrometry
- multiple sclerosis
- cell cycle arrest
- magnetic resonance
- high throughput
- ms ms
- single cell
- electronic health record
- essential oil
- big data
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- nitric oxide synthase
- data analysis
- deep learning
- molecular dynamics simulations