Thyroid cytology smear slides: An untapped resource for ThyroSeq testing.

Marina N Nikiforova Marcos LepeLindsey A TolinoMegan E MillerN Paul OhoriAbigail I WaldMichael S Landau Cihan Kaya Umberto Malapelle Claudio Bellevicine Giancarlo Troncone Yuri E Nikiforov Zubair W Baloch

Published in: Cancer cytopathology (2020)

Thyroid FNA cytology smear slides with adequate cellularity can be successfully used for ThyroSeq GC testing in approximately 80% of cases, with an even higher success rate in Pap-stained smears. Compared with FNA samples collected into preservative solution, 94% to 100% of different genetic alterations could be accurately detected in smears, validating cytology smears as an alternative for ThyroSeq testing in patients with indeterminate thyroid cytology.

Keyphrases

fine needle aspiration
ultrasound guided
pulmonary tuberculosis
genome wide
gene expression
copy number
mass spectrometry