The use of specific antibodies in inflammatory myopathies has improved the characterization of this disease, identifying different clinical phenotypes. Patients with dermatomyositis (DM) and anti-MDA5 antibodies display typical skin symptoms, lesser muscular involvement, and a prevalence of interstitial lung disease (ILD) of up to 91%. Beyond ILD, spontaneous pneumomediastinum (SN) has been identified as a rare but potentially fatal pulmonary manifestation. Two cases of this complication in patients with anti-MDA5 DM are reported.
Keyphrases
- interstitial lung disease
- systemic sclerosis
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- breast cancer cells
- pulmonary hypertension
- cell cycle arrest
- resistance training
- risk factors
- type diabetes
- depressive symptoms
- adipose tissue
- skeletal muscle
- disease activity
- glycemic control
- metabolic syndrome
- body composition
- cell death
- wound healing
- insulin resistance
- high intensity